An extended interaction site determines binding between AP180 and AP2 in clathrin mediated endocytosis
Abstract The early phases of clathrin mediated endocytosis are organized through a highly complex interaction network mediated by clathrin associated sorting proteins (CLASPs) that comprise long intrinsically disordered regions (IDRs).AP180 is a CLASP exclusively expressed in neurons and comprises a long IDR of around 600 residues, whose function r